Mode of Action of Polygodial, an Antifungal Sesquiterpene Dialdehyde
نویسندگان
چکیده
منابع مشابه
Assessment of mechanisms involved in antinociception caused by sesquiterpene polygodial.
Polygodial, a sesquiterpene isolated from the bark of Drymis winteri given systemically, intraplantarly, or by spinal or supraspinal sites, produced antinociception when assessed in both phases of the formalin test and against capsaicin-induced pain. Polygodial, even at high doses, had no antinociceptive or antihyperalgesic effect when assessed in hot-plate assay or in glutamate-induced hyperal...
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The sordarin family of compounds, characterized by a unique tetracyclic diterpene core including a norbornene system, inhibits protein synthesis in fungi by stabilizing the ribosome/EF2 complex. This mode of action is in contrast to typical antifungals, which target the cell membrane. This unusual bioactivity makes sordarin a promising candidate for the development of new fungicidal agents, and...
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Filipin at low concentrations rapidly hemolyzes bovine erythrocytes. Of the compounds tested, which were known a constituents of cell membranes, only cholesterol and phosphatidyl-choline prevented hemolysis. A specific complex was formed only with cholesterol. Filipin treatment caused a release of cholesterol from erythrocytes. Since all cell sterol is located in the cell membrane, the hemolyti...
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Polygodial, a valuable sesquiterpene dialdehyde featuring an epimerizable stereocenter was efficiently extracted and isolated in gram-scale quantities (3.3% w/w) from Tasmannia lanceolata (Tasmanian native pepper) via a recently developed rapid pressurised hot water extraction (PHWE) technique that utilises an unmodified household espresso machine. This method was compared to the maceration of ...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1988
ISSN: 0002-1369
DOI: 10.1080/00021369.1988.10868863